A Bacterial Effector Protein Hijacks Plant Metabolism to Support Pathogen Nutrition.
Identifieur interne : 000243 ( Main/Exploration ); précédent : 000242; suivant : 000244A Bacterial Effector Protein Hijacks Plant Metabolism to Support Pathogen Nutrition.
Auteurs : Liu Xian [République populaire de Chine] ; Gang Yu [République populaire de Chine] ; Yali Wei [République populaire de Chine] ; Jose S. Rufian [République populaire de Chine] ; Yansha Li [République populaire de Chine] ; Haiyan Zhuang [République populaire de Chine] ; Hao Xue [République populaire de Chine] ; Rafael J L. Morcillo [République populaire de Chine] ; Alberto P. Macho [République populaire de Chine]Source :
- Cell host & microbe [ 1934-6069 ] ; 2020.
Abstract
Many bacterial plant pathogens employ a type III secretion system to inject effector proteins within plant cells to suppress plant immunity. Whether and how effector proteins also co-opt plant metabolism to support extensive bacterial replication remains an open question. Here, we show that Ralstonia solanacearum, the causal agent of bacterial wilt disease, secretes the effector protein RipI, which interacts with plant glutamate decarboxylases (GADs) to alter plant metabolism and support bacterial growth. GADs are activated by calmodulin and catalyze the biosynthesis of gamma-aminobutyric acid (GABA), an important signaling molecule in plants and animals. RipI promotes the interaction of GADs with calmodulin, enhancing the production of GABA. R. solanacearum is able to replicate efficiently using GABA as a nutrient, and both RipI and plant GABA contribute to a successful infection. This work reveals a pathogenic strategy to hijack plant metabolism for the biosynthesis of nutrients that support microbial growth during plant colonization.
DOI: 10.1016/j.chom.2020.07.003
PubMed: 32735848
Affiliations:
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Morcillo</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 201602, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 201602</wicri:regionArea><wicri:noRegion>Shanghai 201602</wicri:noRegion></affiliation></author><author><name sortKey="Macho, Alberto P" sort="Macho, Alberto P" uniqKey="Macho A" first="Alberto P" last="Macho">Alberto P. Macho</name><affiliation wicri:level="1"><nlm:affiliation>Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 201602, China. Electronic address: alberto.macho@sibs.ac.cn.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 201602</wicri:regionArea><wicri:noRegion>Shanghai 201602</wicri:noRegion></affiliation></author></analytic><series><title level="j">Cell host & microbe</title><idno type="eISSN">1934-6069</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Many bacterial plant pathogens employ a type III secretion system to inject effector proteins within plant cells to suppress plant immunity. Whether and how effector proteins also co-opt plant metabolism to support extensive bacterial replication remains an open question. Here, we show that Ralstonia solanacearum, the causal agent of bacterial wilt disease, secretes the effector protein RipI, which interacts with plant glutamate decarboxylases (GADs) to alter plant metabolism and support bacterial growth. GADs are activated by calmodulin and catalyze the biosynthesis of gamma-aminobutyric acid (GABA), an important signaling molecule in plants and animals. RipI promotes the interaction of GADs with calmodulin, enhancing the production of GABA. R. solanacearum is able to replicate efficiently using GABA as a nutrient, and both RipI and plant GABA contribute to a successful infection. This work reveals a pathogenic strategy to hijack plant metabolism for the biosynthesis of nutrients that support microbial growth during plant colonization.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32735848</PMID><DateRevised><Year>2020</Year><Month>10</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1934-6069</ISSN><JournalIssue CitedMedium="Internet"><Volume>28</Volume><Issue>4</Issue><PubDate><Year>2020</Year><Month>10</Month><Day>07</Day></PubDate></JournalIssue><Title>Cell host & microbe</Title><ISOAbbreviation>Cell Host Microbe</ISOAbbreviation></Journal><ArticleTitle>A Bacterial Effector Protein Hijacks Plant Metabolism to Support Pathogen Nutrition.</ArticleTitle><Pagination><MedlinePgn>548-557.e7</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S1931-3128(20)30399-1</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.chom.2020.07.003</ELocationID><Abstract><AbstractText>Many bacterial plant pathogens employ a type III secretion system to inject effector proteins within plant cells to suppress plant immunity. Whether and how effector proteins also co-opt plant metabolism to support extensive bacterial replication remains an open question. Here, we show that Ralstonia solanacearum, the causal agent of bacterial wilt disease, secretes the effector protein RipI, which interacts with plant glutamate decarboxylases (GADs) to alter plant metabolism and support bacterial growth. GADs are activated by calmodulin and catalyze the biosynthesis of gamma-aminobutyric acid (GABA), an important signaling molecule in plants and animals. RipI promotes the interaction of GADs with calmodulin, enhancing the production of GABA. R. solanacearum is able to replicate efficiently using GABA as a nutrient, and both RipI and plant GABA contribute to a successful infection. This work reveals a pathogenic strategy to hijack plant metabolism for the biosynthesis of nutrients that support microbial growth during plant colonization.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Xian</LastName><ForeName>Liu</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 201602, China; University of Chinese Academy of Sciences, Beijing 100049, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yu</LastName><ForeName>Gang</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 201602, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wei</LastName><ForeName>Yali</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 201602, China; University of Chinese Academy of Sciences, Beijing 100049, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rufian</LastName><ForeName>Jose S</ForeName><Initials>JS</Initials><AffiliationInfo><Affiliation>Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 201602, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Yansha</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 201602, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhuang</LastName><ForeName>Haiyan</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 201602, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xue</LastName><ForeName>Hao</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 201602, China; University of Chinese Academy of Sciences, Beijing 100049, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Morcillo</LastName><ForeName>Rafael J L</ForeName><Initials>RJL</Initials><AffiliationInfo><Affiliation>Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 201602, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Macho</LastName><ForeName>Alberto P</ForeName><Initials>AP</Initials><AffiliationInfo><Affiliation>Shanghai Center for Plant Stress Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 201602, China. Electronic address: alberto.macho@sibs.ac.cn.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>07</Month><Day>30</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Cell Host Microbe</MedlineTA><NlmUniqueID>101302316</NlmUniqueID><ISSNLinking>1931-3128</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">GABA</Keyword><Keyword MajorTopicYN="Y">GAD</Keyword><Keyword MajorTopicYN="Y">Ralstonia</Keyword><Keyword MajorTopicYN="Y">calmodulin</Keyword><Keyword MajorTopicYN="Y">effector</Keyword><Keyword MajorTopicYN="Y">metabolism</Keyword><Keyword MajorTopicYN="Y">nutrition</Keyword><Keyword MajorTopicYN="Y">virulence</Keyword></KeywordList><CoiStatement>Declaration of Interests The authors declare no competing interests.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>10</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>04</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>06</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>8</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>8</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>8</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32735848</ArticleId><ArticleId IdType="pii">S1931-3128(20)30399-1</ArticleId><ArticleId IdType="doi">10.1016/j.chom.2020.07.003</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Xian, Liu" sort="Xian, Liu" uniqKey="Xian L" first="Liu" last="Xian">Liu Xian</name></noRegion><name sortKey="Li, Yansha" sort="Li, Yansha" uniqKey="Li Y" first="Yansha" last="Li">Yansha Li</name><name sortKey="Macho, Alberto P" sort="Macho, Alberto P" uniqKey="Macho A" first="Alberto P" last="Macho">Alberto P. Macho</name><name sortKey="Morcillo, Rafael J L" sort="Morcillo, Rafael J L" uniqKey="Morcillo R" first="Rafael J L" last="Morcillo">Rafael J L. Morcillo</name><name sortKey="Rufian, Jose S" sort="Rufian, Jose S" uniqKey="Rufian J" first="Jose S" last="Rufian">Jose S. Rufian</name><name sortKey="Wei, Yali" sort="Wei, Yali" uniqKey="Wei Y" first="Yali" last="Wei">Yali Wei</name><name sortKey="Xue, Hao" sort="Xue, Hao" uniqKey="Xue H" first="Hao" last="Xue">Hao Xue</name><name sortKey="Yu, Gang" sort="Yu, Gang" uniqKey="Yu G" first="Gang" last="Yu">Gang Yu</name><name sortKey="Zhuang, Haiyan" sort="Zhuang, Haiyan" uniqKey="Zhuang H" first="Haiyan" last="Zhuang">Haiyan Zhuang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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